The secretary told us he was in a meeting, although we knew he was in his office.

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inspite of versus although

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in spite of / despite / although

In spite of, despite and although are all used to show a contrast but there are differences in the structures used with them.

In spite of / despite

After in spite of and despite we use a noun or a pronoun.

    We enjoyed our camping holiday in spite of the rain.
    Despite the pain in his leg he completed the marathon.
    Despite having all the necessary qualifications, they didn’t offer me the job.

Remember that the gerund (‘-ing’ form) is the ‘noun’ form of a verb.

The only difference between in spite of and despite is the ‘of’.

    Despite of the bad weather, there was a large crowd at the match.

Although

After although we use a subject and a verb.

    We enjoyed our camping holiday although it rained every day.
    Although he worked very hard, he didn’t manage to pass the exam.
    The holiday was great although the hotel wasn’t very nice.

We can use in spite of and despite with a subject and verb if we include the expression ‘the fact that’.

    In spite of the fact that he worked very hard, he didn’t manage to pass the exam.
    Despite the fact that he worked very hard, he didn’t manage to pass the exam.

Even though

Even though is a slightly stronger form of although.

    We decided to buy the house even though we didn’t really have enough money.
    You keep making that stupid noise even though I’ve asked you to stop three times.

Like although, even though is followed by a subject and a verb.

แหล่งที่มา
http://learnenglish.britishcouncil.org/en/grammar-reference/spite-despite-although