คือมันเป็นศัพท์เฉพาะที่ผมไม่รู้น่ะครับ เท่าที่ผมแปลออกคือมันสามารถทานคู่กันได้ใช่ไหมครับ
แต่การทานคู่กันจะทำให้ฤิทธิ์ของ propranolol แรงขึ้น (แรงขึ้นกี่เท่า?)
อ้างใน
https://www.drugs.com/drug-interactions/cymbalta-with-propranolol-949-2273-1956-0.html
Interactions between your selected drugs
Moderate
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
propranolol ↔ duloxetine
Applies to:propranolol and Cymbalta (duloxetine)
DULoxetine may increase the blood levels and effects of propranolol. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
MONITOR: Duloxetine is a moderate inhibitor of CYP450 2D6 and may increase the plasma concentrations of drugs that are substrates of the isoenzyme. According to the product labeling, when duloxetine (60 mg twice a day) was administered in conjunction with a single 50 mg dose of desipramine, a CYP450 2D6 substrate, the systemic exposure (AUC) of desipramine increased 3-fold. Conversely, many CYP450 2D6 substrates can also be competitive or noncompetitive inhibitors of the isoenzyme and may increase the plasma concentrations of duloxetine, which is partially metabolized by CYP450 2D6.
MANAGEMENT: Caution is advised if duloxetine must be used concomitantly with medications that undergo metabolism by CYP450 2D6, particularly those with a narrow therapeutic range such as tricyclic antidepressants, phenothiazines, beta blockers, and class IC antiarrhythmic agents (e.g., propafenone, flecainide). A lower initial dosage, as well as clinical and laboratory monitoring, may be appropriate for some drugs.
ถามเรื่องปฏิกิริยา (Interactions) ระหว่างยา propranolol และ duloxetine
แต่การทานคู่กันจะทำให้ฤิทธิ์ของ propranolol แรงขึ้น (แรงขึ้นกี่เท่า?)
อ้างใน https://www.drugs.com/drug-interactions/cymbalta-with-propranolol-949-2273-1956-0.html
Interactions between your selected drugs
Moderate
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
propranolol ↔ duloxetine
Applies to:propranolol and Cymbalta (duloxetine)
DULoxetine may increase the blood levels and effects of propranolol. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
MONITOR: Duloxetine is a moderate inhibitor of CYP450 2D6 and may increase the plasma concentrations of drugs that are substrates of the isoenzyme. According to the product labeling, when duloxetine (60 mg twice a day) was administered in conjunction with a single 50 mg dose of desipramine, a CYP450 2D6 substrate, the systemic exposure (AUC) of desipramine increased 3-fold. Conversely, many CYP450 2D6 substrates can also be competitive or noncompetitive inhibitors of the isoenzyme and may increase the plasma concentrations of duloxetine, which is partially metabolized by CYP450 2D6.
MANAGEMENT: Caution is advised if duloxetine must be used concomitantly with medications that undergo metabolism by CYP450 2D6, particularly those with a narrow therapeutic range such as tricyclic antidepressants, phenothiazines, beta blockers, and class IC antiarrhythmic agents (e.g., propafenone, flecainide). A lower initial dosage, as well as clinical and laboratory monitoring, may be appropriate for some drugs.