- A suggested daily intake or tolerable upper intake for arginine is lacking. The therapeutic dosage (maximum dose considered to be safe) is 400-6,000 milligrams.
- Two grams of L-arginine has been taken three times daily for six weeks
- 12 grams of L-arginine has been taken by mouth daily for four weeks.
- A dose of 0.5-1.5 grams of L-arginine per 10 kilograms of body weight has been taken by mouth for one week.
- Doses of 4-24 grams have been taken by mouth daily for 2-24 weeks.
- A single dose of two grams of L-arginine as an adjunct to 60 milligrams of isosorbide mononitrate has been taken by mouth.